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ADRENAL GLAND * ADRENOCORTICAL HYPERFUNCTION (HYPERADRENALISM): 1) Cushing syndrome, characterized by an excess of cortisol. 2) Hyperaldosteronism. 3) Adrenogenital or virilizing syndromes, caused by an excess of androgens. The clinical features of some of these syndromes overlap approximately because of the co-occur functions of some of the adrenal steroids. * Hypercortisolism (Cushing Syndrome): * This dis prescribe is caused by some(prenominal) modify that produces an elevation in glucocorticoid levels. * Causes: * Exogenous glucocorticoids. * Endogenous glucocorticoids * Causes of endogenetic hyper secernment: * Primary hypothalamic-pituitary diseases associated with hypersecretion of ACTH. * Primary adrenocortical hyperplasia or neoplasia * The secretion of ectopic ACTH by nonendocrine neoplasms * * Primary hypothalamic-pituitary Cushing disease: * > half(a) of the case s , wo workforce: men 5:1 . 20s and 30s. In legal age of cases, ACTH-producing microadenoma (without mass effects) or macroadenomas (>10 mm).

In the remaining patients, corticotroph carrel hyperplasia * The adrenal glands install bilateral nodular cortical hyperplasia lead story to hypercortisolism * Primary adrenal lesions: ACTH-independent Cushing syndrome or adrenal Cushing syndrome * (10% to 20% of cases) adenoma , carcinoma, and primeval cortical hyperplasia. * The last mentioned have two variants : macronodules (>3 mm) and micronodules (<3 mm) that are a lot pigm ented (primary pigmented nodular adrenocorti! cal disease). The micronodular variant is a familial disease, usually associated with features of overactivity in other endocrine organs such as the pituitary, thyroid, and gonads * syllable structure: * The pituitary in Cushing syndrome shows changes disregarding of the cause. The most common accommodation is termed Crooke hyaline change. * The adrenal glands depends on the cause of the hypercortisolism. The...If you want to subscribe a full essay, order it on our website: OrderCustomPaper.com

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