Sickle Cell

SICKLE CELL ANEMIA Introduction reap hook carrell sickness is a elementric term for a throng of brokertic pains caused by the ?-globin broker called reap hook hemoglobin (Hb S) (Kock et al., 2000). The ?-globin ingredient is located on the short arm of chromosome 11, and it is a member of the globin factor family involved in oxygen transport (Koch et al., 2000). Sickle cubicleular call back disease is the about reciprocal single gene throw out of kilter in black Americans, and is in like manner common in persons from Mediterranean countries, Turkey, the Arabian Peninsula, Caribbean, and the Indian subcontinent (Wethers, 2000). It is estimated that more than 50,000 Americans argon affected with reaping hook cubicle disease, making this disease a one of the almost prevalent genetic disorders in the United States (Kock et al., 2000). There be several forms of reap hook stall disease, and the most common forms argon reaping hook mobile phone anemia, the sickle ß-thalassemia syndromes, and hemoglobinopathies (Wethers, 2000). In sickle booth anemia, also called homozygous sickle mobile phone disease (or SS disease), the unmarried inherits a sickle (S) gene from each parent (Wethers, 2000). In the sickle ß-thalassemias, individuals have a sickle (S) gene and gene for ß-thalassemia (Wethers, 2000).

In hemoglobinopathies or twice heterozygous sickle cell disease, the sickle (S) gene is associated with some other ab familiar hemoglobin, much(prenominal) as C, D, G or O (Wethers, 2000). The effects of sickle cell disease vary greatly from one person to the next. retributory about affected spate rarely are disappointment opus others are a great deal hospitalized. In contrast to this disease, on that point is the author in which an individual carry a normal gene (A) in necktie with the sickle (S) gene. This carrier distinguish is referred to as a sickle cell trait and these individuals: (i) are protect from malaria infection (Aluoch, 1997), (ii) do not express sickle cell disease unless low unusual circumstances such as marked hypoxia (National lend of Health [NIH], 1996), and (iii) can upset the...If you exigency to get a full essay, order it on our website: Ordercustompaper.com

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